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Effects of Medicines and Supplements on Spontaneous Pregnancy and Semen Parameters in Male Infertility Article

Jian Li, Qi Wu, Ernest Hung Yu Ng, Ben Willem J. Mol, Xiao Ke Wu, Chi Chiu Wang

Engineering 2022, Volume 16, Issue 9, Pages 198-209 doi: 10.1016/j.eng.2021.07.009

Abstract: network meta-analysis (NMA) to compare the effectiveness of medicines and supplements for idiopathic maleinfertility and to identify the best treatment.Infrastructure (CNKI), were searched for the period from January 1990 to June 2021 using the keywords "maleinfertility," "medical therapy," "supplement/nutrient therapy," and relatedIn conclusion, the optimal treatment for male infertility for live birth is still unknown.

Keywords： Male infertility Medicine Supplement Spontaneous pregnancy rate Sperm parameters

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DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren

Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 302-312 doi: 10.1007/s11684-021-0851-8

Abstract: However, the fertility of deficient male mice was markedly impaired, consistent with the high expression

Keywords： Dcaf8 male infertility spermatogenesis

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Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Infertility is experienced by 8%–12% of adults incells (MSCs) are further studied for their possible use in reproductive medicine, particularly for infertilitymanage ovarian and uterine disorders, and each technique presents a novel method for the therapy of infertility

Keywords： infertility stem cell therapy mesenchymal stem cells pluripotent stem cells

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The chromosome breakage rates in 244 cases of the infertility couples

Yu Hongliang,Chang Mingxiu,Cao Henghai,Bo Liwei,Wang Yanli and Wu Yanhong

Strategic Study of CAE 2014, Volume 16, Issue 5, Pages 67-69

Abstract: ">To understand the incidence of chromosome breakage rates for the adverse pregnancy history in the infertilitycouples，we analyzed statistically the chromosomal breakage rates in the infertility couples which haveThe results show that：The male patients average age was 29.07，the female patients average age was 28.15The male patients have founded no breakage accounted for 32.38 % of the total in the male patients，thebe one of the important reasons for embryo damage、miscarriage and other the adverse pregnancy in the infertility

Keywords： infertility couples adverse pregnancy chromosome breakage

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Applying TCM Constitution Theory to Infertility via Omics

Qi Wang

Engineering 2023, Volume 30, Issue 11, Pages 30-31 doi: 10.1016/j.eng.2023.05.005

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Susceptibility of male and female Japanese medaka (

Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 1, Pages 77-84 doi: 10.1007/s11783-012-0466-z

Abstract: 2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka ( ) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. Moreover, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 μg·L . This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP exposure.

Keywords： 2 4 6-trichlorophenol genotoxicity Japanese medaka piscine micronucleus test in peripheral erythrocytes gender difference

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Analysis on municipal identification of male sterilization postoperative complication of Chongqing

Li Chuanhai,Ma Mingfu,Yang Hao and Zhou Shuping

Strategic Study of CAE 2014, Volume 16, Issue 5, Pages 110-112

Abstract: The results show that：In the 56 applicants for municipal identification of male sterilization postoperativecomplications，accounting for 25.2 %；for the self- reported symptoms，25 cases were not coincident with malesterilization postoperative complications，accounting for 44.64 %；the cases coincident with male sterilizationTherefore，the identification of male sterilization postoperative complication should be strictly implementedThe knowledge related to male sterilization should be fully promoted.

Keywords： male sterilization complication municipal identification technical service

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Immunohistochemical measurement and expression of Mcl-1 in infertile testes

Raafat Hegazy,Abdelmonem Hegazy,Mustafa Ammar,Emad Salem

Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 361-367 doi: 10.1007/s11684-015-0395-x

Abstract:

The diagnosis of azoospermia represents a major challenge to andrologists as this condition may occur despite normal spermatogenesis and genital tracts. Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins involved in regulation of apoptosis in various cell types. This study aimed to investigate the immunohistochemical expression of Mcl-1 in testicular biopsies of subjects with azoospermia. Eighty-six cases with azoospermia were obtained from 509 infertile patients admitted to the Andrology Unit of the Zagazig University Hospitals from January 2010 to December 2011. Biopsies were diagnosed and classified using H&E-stained slide sections. The specimens were subjected to immunohistochemical staining for Mcl-1 and examined through light microscopy. Forty-five cases of maturation arrest (25 at spermatids and 20 at the spermatocytes), 31 cases of hypospermatogenesis (20 moderate and 11 severe), 5 cases of Sertoli?cell-only syndrome, 2 cases of basement membrane hyalinization, and 1 case of tubular and peritubular sclerosis were observed. Normal spermatogenesis was detected in 2 cases. A strong positive immunoreaction in Leydig cells was observed among all investigated specimens. A moderate reaction was detected in spermatocytes and spermatozoa in cases of normal spermatogenesis and hypospermatogenesis, but a negative reaction was detected in cases of maturation arrest and germ cell aplasia. Apoptosis was found to be associated with decreased rate of spermatogenesis. High apoptosis rates may result in azoospermia, which can occur despite normal spermatogenesis and absence of duct obstruction.

Keywords： spermatogenesis testis Mcl-1 expression immunohistochemical study infertility

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A 7-year follow-up study of the features and transformations of elderly male patients with OGTT-1h hyperglycemia

TIAN Hui, LI Chunlin, ZHONG Wenwen, PAN Changyu, LU Juming, CAO Xiutang

Frontiers of Medicine 2008, Volume 2, Issue 4, Pages 396-399 doi: 10.1007/s11684-008-0076-0

Abstract: The aim of this paper is to investigate the clinical features and transformation of elderly male patientsSeven years of follow-up visits were performed on 189 elderly male outpatients with OGTT-1h HG and data

Keywords： special attention prevalence unchanged dyslipidemia elderly

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Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome Article

Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi

Engineering 2023, Volume 23, Issue 4, Pages 103-111 doi: 10.1016/j.eng.2022.08.013

Abstract:

Ovulation induction is a first-line medical treatment for infertility in polycystic ovary syndrome/em>, associated with phenylalanine and arachidonic acid metabolites, contributed to the failure of infertility

Keywords： Polycystic ovary syndrome Infertility Ovulation responses ZNF438 REC114 Whole-exome sequencing